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EGFR WT/T790M-IN-3

Product Specifications

Target

Microtubule Associated|||EGFR

Related Pathways

Tyrosine Kinase/Adaptors|||Angiogenesis|||Cytoskeletal Signaling|||JAK/STAT signaling

Bioactivity

EGFRWT/T790M-IN-3 is an irreversible, covalent inhibitor of EGFRWT and EGFRT790M with IC50 values of 28.1 nM and 24.6 nM, respectively. It also inhibits tubulin polymerization, exhibiting an IC50 of 5.1 ?M. EGFRWT/T790M-IN-3 demonstrates significant antiproliferative effects on HCT116 and T47D cells, with IC50 values of 3.12 ?M and 4.12 ?M, respectively. This compound is applicable in research pertaining to cancers such as non-small cell lung cancer, colon cancer, and breast cancer.

Shipping Conditions

Cool pack

Storage Temperature

-20°C

Product Datasheet

https://www.targetmol.com/attachment/DataSheet/390881992805761161/T212301

Available Sizes

Curated Selection

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