TQ-3959
Product Specifications
CAS Number
2926610-43-5
Target
BTK, PROTACs
Related Pathways
Tyrosine Kinase/Adaptors, PROTAC, Angiogenesis
Bioactivity
TQ-3959 is an orally active BTKPROTAC degrader, with a DC50 of 14.6 nM. It exhibits antiproliferative activity against both wild-type BTK and BTK C481S mutant cell lines. TQ-3959 demonstrates tumor growth inhibition in female NOD-SCID mice with TMD-8 xenografts. This compound is applicable in the study of B-cell malignancies, such as lymphoma.
Smiles
O=C1C(C=2C=3C(=CC(=CC3)N4CC(C4)N5CCC(CC5)C6=CC=C(NC7=NC(=CN=C7C(N)=O)N8C[C@@H](CCC8)N9C(=O)N(C)CC9)C=C6)ON2)CCC(=O)N1
Molecular Formula
C40H47N11O5
Molecular Weight
761.87
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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