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MS44

Product Specifications

Target

PROTACs|||Aurora Kinase

Related Pathways

Chromatin/Epigenetic|||PROTAC|||Cell Cycle/Checkpoint

Bioactivity

MS44 is a potent degrader of aurora kinase B (AURKBPROTAC) with a degradation concentration (DC50) of 103 nM. It effectively and selectively degrades AURKB in a time- and ubiquitin-proteasome system (UPS) -dependent manner, showing specificity for AURKB over AURKA and AURKC. MS44 inhibits the proliferation of various cancer cell lines and strongly induces G2/M arrest. It is useful for studying AURKB-dependent tumors.

Shipping Conditions

Cool pack

Storage Temperature

-20°C

Available Sizes

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