ClpP modulator-1
Product Specifications
CAS Number
2363753-48-2
Target
Protease
Related Pathways
Proteases/Proteasome
Bioactivity
ClpPmodulator-1 (Compound BC8a) is a peptide mimic functioning as an allosteric ClpP modulator. At low concentrations, ClpPmodulator-1 acts as a ClpP activator, with EC50 values of 0.35 μM for Neisseria meningitides ClpP (NmClpP) and 0.58 μM for Escherichia coli ClpP (EcClpP) . At higher concentrations, it inhibits peptidase activity by competitively blocking substrate protein (LY-AMC) binding to the ClpPC site. ClpPmodulator-1 exhibits antibacterial properties and is applicable in bacterial infection research.
Smiles
[C@H](C(N[C@@H](CC(C)C)B(O)O)=O)(NC(=O)C1=C(Cl)C=C(OC)C=C1)CC(C)C
Molecular Formula
C19H30BClN2O5
Molecular Weight
412.72
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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