(Rac) -Ibrutinib alkyne
Product Specifications
CAS Number
936563-91-6
Target
Calcium Channel, BTK
Related Pathways
Tyrosine Kinase/Adaptors, Angiogenesis, Metabolism, Membrane transporter/Ion channel
Bioactivity
(Rac) -Ibrutinib alkyne (Compound 8) is a Btk inhibitor with an IC50 of 0.72 nM. This compound effectively inhibits B cell receptor signaling functions, with an IC50 of 9 nM for calcium flux inhibition in Ramos cells. (Rac) -Ibrutinib alkyne is applicable in research on diseases such as rheumatoid arthritis.
Smiles
O=C(C#C)N1CCCC(N2N=C(C=3C=CC(OC=4C=CC=CC4)=CC3)C=5C(=NC=NC52)N)C1
Molecular Formula
C25H22N6O2
Molecular Weight
438.48
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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