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(Rac) -Ibrutinib alkyne

Product Specifications

CAS Number

936563-91-6

Target

Calcium Channel|||BTK

Related Pathways

Tyrosine Kinase/Adaptors|||Angiogenesis|||Metabolism|||Membrane transporter/Ion channel

Bioactivity

(Rac) -Ibrutinib alkyne (Compound 8) is a Btk inhibitor with an IC50 of 0.72 nM. This compound effectively inhibits B cell receptor signaling functions, with an IC50 of 9 nM for calcium flux inhibition in Ramos cells. (Rac) -Ibrutinib alkyne is applicable in research on diseases such as rheumatoid arthritis.

Smiles

O=C(C#C)N1CCCC(N2N=C(C=3C=CC(OC=4C=CC=CC4)=CC3)C=5C(=NC=NC52)N)C1

Molecular Formula

C25H22N6O2

Molecular Weight

438.48

Shipping Conditions

Cool pack

Storage Temperature

-20°C

Available Sizes

Curated Selection

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