TD034
Product Specifications
CAS Number
3030718-42-1
Target
YAP, HDAC
Related Pathways
Chromatin/Epigenetic, Stem Cells, DNA Damage/DNA Repair
Bioactivity
TD034 is a selective, reversible, non-covalent inhibitor of HDAC11, with an IC50 of 5.1 nM and a Ki of 1.5 nM. It does not inhibit other HDACs or sirtuins. TD034 inhibits the desuccinylation of SHMT2 (a substrate of HDAC11) and lowers YAP1 levels by inhibiting HDAC11. TD034 is applicable for lung cancer research.
Smiles
C(CCCCCCCCCC)[C@@H]1[C@@H](C(CCCCC[C@@H]2NC(=O)[C@@]3(N(C(=O)[C@H](CC4=CC=CC=C4)NC(=O)[C@H](CC5=CC=CC=C5)NC2=O)CCCC3)[H])=O)O1
Molecular Formula
C45H64N4O6
Molecular Weight
757.01
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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