What is the catalog number for RGN6024?

The catalog number for RGN6024 is T212175.

What sizes are available for RGN6024?

RGN6024 is available in the following size(s): 10 mg, 50 mg.

How many pack sizes does RGN6024 come in?

RGN6024 is available in 2 different pack sizes.

RGN6024 is currently made to order / not held in immediate stock. Contact us for lead time.

Who manufactures RGN6024?

RGN6024 is manufactured by Molfinity.

What is the estimated delivery time for RGN6024?

Estimated delivery time for RGN6024 is approximately 10 business day(s), depending on your location.

RGN6024

Product Specifications

CAS Number

3055038-20-2

Target

Microtubule Associated

Related Pathways

Cytoskeletal Signaling

Bioactivity

RGN6024 is an orally active, reversible small molecule that can penetrate the blood-brain barrier and acts as a microtubule (tubulin) destabilizer. It inhibits microtubule polymerization in both biochemical and cellular assays. RGN6024 binds to the colchicine-binding site of β-tubulin with affinity constants of Kd= 6.7 μM (SPR) and Kd= 7.4 μM (tryptophan assay), inducing G2/M phase arrest in glioblastoma (GB) cells. The compound remains effective in cells overexpressing βIII-tubulin. Additionally, RGN6024 is able to suppress tumor growth in glioblastoma (GB) xenograft mouse models. This compound is applicable for research in glioblastoma (GB) .