RGN6024
Product Specifications
CAS Number
3055038-20-2
Target
Microtubule Associated
Related Pathways
Cytoskeletal Signaling
Bioactivity
RGN6024 is an orally active, reversible small molecule that can penetrate the blood-brain barrier and acts as a microtubule (tubulin) destabilizer. It inhibits microtubule polymerization in both biochemical and cellular assays. RGN6024 binds to the colchicine-binding site of ?-tubulin with affinity constants of Kd= 6.7 ?M (SPR) and Kd= 7.4 ?M (tryptophan assay), inducing G2/M phase arrest in glioblastoma (GB) cells. The compound remains effective in cells overexpressing ?III-tubulin. Additionally, RGN6024 is able to suppress tumor growth in glioblastoma (GB) xenograft mouse models. This compound is applicable for research in glioblastoma (GB) .
Smiles
O=C(NC1=NC=C(OC2=CN=C(N=C2)N3CCOCC3)S1)C45CC(OC)(C4)C5
Molecular Formula
C18H21N5O4S
Molecular Weight
403.46
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
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