Nogo-B-IN-1
Product Specifications
Target
Apoptosis, NF-κB, Bcl-2 Family, Akt, PI3K
Related Pathways
Apoptosis, Cytoskeletal Signaling, PI3K/Akt/mTOR signaling, NF-κB
Bioactivity
Nogo-B-IN-1 ((S, R) -4v) is a covalent inhibitor targeting Nogo-B. It suppresses osteosarcoma (OS) progression by inhibiting Nogo-B activity and the PI3K/AKT/NF-κB/Bcl-2 signaling pathways. Nogo-B-IN-1 hinders proliferation of OS 143B cells (IC50= 0.28 μM) and induces apoptosis. This compound is applicable for targeted OS research.
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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