Nogo-B-IN-1
Product Specifications
Target
Apoptosis|||NF-?B|||Bcl-2 Family|||Akt|||PI3K
Related Pathways
Apoptosis|||Cytoskeletal Signaling|||PI3K/Akt/mTOR signaling|||NF-?B
Bioactivity
Nogo-B-IN-1 ((S, R) -4v) is a covalent inhibitor targeting Nogo-B. It suppresses osteosarcoma (OS) progression by inhibiting Nogo-B activity and the PI3K/AKT/NF-?B/Bcl-2 signaling pathways. Nogo-B-IN-1 hinders proliferation of OS 143B cells (IC50= 0.28?µM) and induces apoptosis. This compound is applicable for targeted OS research.
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
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