MMRi6
Product Specifications
CAS Number
709009-15-4
Target
PARP|||MDM-2/p53
Related Pathways
DNA Damage/DNA Repair|||Apoptosis|||Chromatin/Epigenetic
Bioactivity
MMRi6 is an inhibitor of the Mdm2-MdmX RING domain, capable of disrupting Mdm2-MdmX RING-RING interactions in vitro. It inhibits MdmX-stimulated Mdm2 autoubiquitination and Mdm2-MdmX-mediated polyubiquitination of p53 without affecting NEDD4-1 autoubiquitination. In wt-p53 Emu-myc lymphoma cells, MMRi6 induces p53 stabilization and accumulation, as well as PARP cleavage. It inhibits the growth of wt-p53 and p53-null Emu-myc lymphoma cells, with IC50 values of approximately 0.5 ?M and 3 ?M, respectively. MMRi6 is applicable in leukemia/lymphoma research.
Smiles
ClC1=CC=CC(=C1)C(NC2=NC=CC=C2)C3=CC(Cl)=C4C=CC=NC4=C3O
Molecular Formula
C21H15Cl2N3O
Molecular Weight
396.27
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
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