What is the catalog number for MCB-36?

The catalog number for MCB-36 is T212089.

What sizes are available for MCB-36?

MCB-36 is available in the following size(s): 10 mg, 50 mg.

How many pack sizes does MCB-36 come in?

MCB-36 is available in 2 different pack sizes.

MCB-36 is currently made to order / not held in immediate stock. Contact us for lead time.

Who manufactures MCB-36?

MCB-36 is manufactured by Molfinity.

What is the estimated delivery time for MCB-36?

Estimated delivery time for MCB-36 is approximately 10 business day(s), depending on your location.

MCB-36

Product Specifications

Target

PERK, Apoptosis, PROTACs, Caspase, p38 MAPK, Ras, TNF

Related Pathways

Proteases/Proteasome, PROTAC, Apoptosis, MAPK

Bioactivity

MCB-36 is a versatile KRAS-targeting PROTAC degrader recruiting the VHL protein without affecting KRAS transcription. It exerts minimal impact on HRAS and NRAS protein levels. MCB-36 binds with high affinity (Kd ≈ 1 pM) to G12D, G12C, G12V, and wild-type KRAS in the GDP-loaded state. By reducing p-ERK levels, MCB-36 induces apoptosis (apoptosis) . It effectively inhibits cancer cells resistant to KRASG12C and remodels the tumor immune microenvironment. MCB-36 is applicable in research on colorectal and lung cancer.