JAK1-IN-18
Product Specifications
CAS Number
2459377-98-9
Target
JAK
Related Pathways
Angiogenesis, Tyrosine Kinase/Adaptors, JAK/STAT signaling, Chromatin/Epigenetic, Stem Cells
Bioactivity
JAK1-IN-18 (Example 2) is a selective JAK1 inhibitor with an IC50 value of 0.15 nM, demonstrating significantly greater inhibitory potency for JAK1 compared to JAK2 and JAK3. It significantly reduces inflammation in ulcerative colitis (UC) mouse models induced by DSS and Crohn's disease (CD) rat models induced by DNBS. JAK1-IN-18 is applicable for research into autoimmune diseases (such as inflammatory bowel disease), viral infections (such as hepatitis B virus infection), and cancers (such as hematologic malignancies) .
Smiles
N(C1=C2C(=NC=C1C(N)=O)NC=C2)N3C[C@@H](C(NCC(F)F)=O)CCC3
Molecular Formula
C16H20F2N6O2
Molecular Weight
366.37
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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