N-Didesmethyladitoprim
Product Specifications
CAS Number
56066-19-4
Target
Antifolate|||Drug Metabolite|||Antibacterial
Related Pathways
Cell Cycle/Checkpoint|||Microbiology/Virology|||Metabolism
Bioactivity
N-Didesmethyladitoprim is a metabolite of Aditoprim, which acts as a selective inhibitor of bacterial dihydrofolate reductase (DHFR) . Aditoprim exhibits inhibitory concentration (IC50) values of 47 nM for Escherichia coli and 520 nM for Lactobacillus casei DHFR. It impedes the reduction of dihydrofolate to tetrahydrofolate. Aditoprim demonstrates broad-spectrum antibacterial activity and excellent pharmacokinetics.
Smiles
N=1C=C(C(=NC1N)N)CC2=CC(OC)=C(N)C(OC)=C2
Molecular Formula
C13H17N5O2
Molecular Weight
275.31
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
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