DeFer-2
Product Specifications
CAS Number
3058911-16-0
Target
ROS, PROTACs, Pyroptosis, Caspase
Related Pathways
PROTAC, Immunology/Inflammation, Apoptosis, Proteases/Proteasome
Bioactivity
DeFer-2 is a ferritin PROTAC degrader (Kd= 17.1 μM) . It triggers the degradation of ferritin leading to the accumulation of free iron ions and an increase in ROS, which subsequently initiates caspase 3-GSDME mediated pyroptosis in cancer cells. DeFer-2 significantly inhibits tumor growth and extends the survival of mice with subcutaneous B16F10 tumors, and it is useful for melanoma research.
Smiles
C([C@@H](NC(CCCNC(CCCCCCC/C=C\CCCCCCCC)=O)=O)[C@](C)(C)C)(=O)N1[C@H](C(NCC2=CC=C(C=C2)C=3SC=NC3C)=O)C[C@@H](O)C1
Molecular Formula
C44H69N5O5S
Molecular Weight
780.11
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
More Discoveries
Explore Other Products
Browse additional items from our catalog
K0434906 1.0 µg DNA
CEP170L sgRNA CRISPR/Cas9 All-in-One Lentivector (Human) (Target 1)
Sign In for Pricing
View Details 
LV668282 1.0 µg DNA
CACNG3 Lentiviral Vector (Rat) (CMV) (pLenti-GIII-CMV-C-term-HA)
Sign In for Pricing
View Details 
134729-AP 100 µL
TRIM23 (E3 Ubiquitin-protein Ligase TRIM23, ADP-ribosylation Factor Domain-containing Protein 1, GTP-binding Protein ARD-1, RING Finger Protein 46, Tripartite Motif-containing Protein 23, ARD1, ARFD1, RNF46) (AP) discontinued
Sign In for Pricing
View Details NBP2-89862R 0.1 mL
Rabbit Monoclonal Peroxiredoxin 5 Antibody (002) [DyLight 550]
Sign In for Pricing
View Details ARP56475_P050-Biotin 100 µL
Psmc1 Antibody - N-terminal region : Biotin (ARP56475_P050-Biotin)
Sign In for Pricing
View Details