DeFer-2
Product Specifications
CAS Number
3058911-16-0
Target
ROS, PROTACs, Pyroptosis, Caspase
Related Pathways
PROTAC, Immunology/Inflammation, Apoptosis, Proteases/Proteasome
Bioactivity
DeFer-2 is a ferritin PROTAC degrader (Kd= 17.1 μM) . It triggers the degradation of ferritin leading to the accumulation of free iron ions and an increase in ROS, which subsequently initiates caspase 3-GSDME mediated pyroptosis in cancer cells. DeFer-2 significantly inhibits tumor growth and extends the survival of mice with subcutaneous B16F10 tumors, and it is useful for melanoma research.
Smiles
C([C@@H](NC(CCCNC(CCCCCCC/C=C\CCCCCCCC)=O)=O)[C@](C)(C)C)(=O)N1[C@H](C(NCC2=CC=C(C=C2)C=3SC=NC3C)=O)C[C@@H](O)C1
Molecular Formula
C44H69N5O5S
Molecular Weight
780.11
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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