What is the catalog number for YH-0623?

The catalog number for YH-0623 is T212048.

What sizes are available for YH-0623?

YH-0623 is available in the following size(s): 10 mg, 50 mg.

How many pack sizes does YH-0623 come in?

YH-0623 is available in 2 different pack sizes.

YH-0623 is currently made to order / not held in immediate stock. Contact us for lead time.

Who manufactures YH-0623?

YH-0623 is manufactured by Molfinity.

What is the estimated delivery time for YH-0623?

Estimated delivery time for YH-0623 is approximately 10 business day(s), depending on your location.

YH-0623

Product Specifications

Target

OXPHOS, Mitochondrial Metabolism, PDGFR, DNA/RNA Synthesis

Related Pathways

Cell Cycle/Checkpoint, DNA Damage/DNA Repair, Metabolism, Tyrosine Kinase/Adaptors, Angiogenesis, Apoptosis

Bioactivity

YH-0623 is an orally active inhibitor of mitochondrial RNA polymerase (POLRMT) with an IC50 of 50.48 nM as determined by NanoBRET assay. It exhibits antiproliferative effects on 22Rv1 cells by downregulating mitochondrial gene expression. YH-0623 suppresses 22Rv1 cell growth, colony formation, and expression of proteins related to OXPHOS. Significant tumor growth inhibition was observed in a prostate cancer xenograft mouse model. YH-0623 is applicable for prostate cancer research.