EGFR T790M/VEGFR-2-IN-1

EGFRT790M/VEGFR-2-IN-1 (Compound 6) is a dual inhibitor targeting the EGFRT790M mutant (IC50=0.26 ?M) and VEGFR-2 (IC50=0.95 ?M) . It effectively blocks tumor cell proliferation and angiogenesis signaling pathways. This compound exhibits potent cytotoxicity against various cancer cell lines (HCT116, MCF-7, HepG2, A549; IC50=5.35-9.90 ?M) and holds potential for research in non-small cell lung cancer and solid tumors.