Hedgehog IN-11
Product Specifications
Target
Hedgehog/Smoothened|||DNA Methyltransferase|||Apoptosis
Related Pathways
GPCR/G Protein|||Stem Cells|||Apoptosis|||Chromatin/Epigenetic
Bioactivity
HedgehogIN-11 is an orally active Hedgehog inhibitor. It reduces resistance to Temozolomide (TMZ) by downregulating O6-methylguanine-deoxyribonucleotides methyltransferase (MGMT) expression through the Hedgehog pathway. HedgehogIN-11 significantly inhibits the migration and invasion of TMZ-resistant glioblastoma cells and induces apoptosis. Computational modeling predicts good blood-brain barrier penetration for HedgehogIN-11. This compound is applicable for glioblastoma (GBM) research.
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
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