DDO-4033
Product Specifications
Target
E1/E2/E3 Enzyme, YAP
Related Pathways
Stem Cells, Ubiquitination
Bioactivity
DDO-4033 is an SPOP inhibitor with an IC50 of 16.9 μM and a Kd of 15.1 μM. It hinders the malignant migration, invasion, and proliferation of clear cell renal cell carcinoma (ccRCC) cell lines. DDO-4033 disrupts the recruitment of the substrate LATS1 by SPOP, inhibiting its polyubiquitination and subsequent degradation, which leads to the upregulation of LATS1 expression. This compound demonstrates significant antitumor activity and can be utilized in renal cell carcinoma research.
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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