EP2 receptor antagonist-3
Product Specifications
CAS Number
1799626-16-6
Target
Prostaglandin Receptor, Beta Amyloid
Related Pathways
Immunology/Inflammation, Neuroscience, GPCR/G Protein
Bioactivity
EP2 receptor antagonist-3 is a selective antagonist of the EP2 receptor, with an IC50 of 8 nM determined in the hEP2 SPA assay and an IC50 of 50 nM in the hEP2 cAMP assay. It enhances macrophage-mediated clearance of Amyloid-β plaques. In CD-1 mice, it shows moderate clearance and good exposure, and exhibits good central nervous system (CNS) exposure in both mice and rats. EP2 receptor antagonist-3 is applicable for research in Alzheimer's disease.
Smiles
O=C1C=C(C=CN1)CN2CC3=CC(=CC(Cl)=C3OCC2)N4C=CC=5C=C(F)C=CC54
Molecular Formula
C23H19ClFN3O2
Molecular Weight
423.87
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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