Carmaphycin-17
Product Specifications
CAS Number
2143080-91-3
Target
Proteasome, Parasite
Related Pathways
Microbiology/Virology, Proteases/Proteasome, Ubiquitination
Bioactivity
Carmaphycin-17 (CP-17) is a selective proteasome inhibitor with an EC50 of 217 nM. It exhibits potent antimicrobial activity against Trichomonas vaginalis and can overcome resistance to Metronidazole. In mouse models of vaginal trichomoniasis, CP-17 significantly reduces parasite burden after topical treatment without any observed adverse effects. Additionally, Carmaphycin-17 is useful for researching sexually transmitted diseases like trichomoniasis.
Smiles
C([C@@H](C(N[C@H](C(=O)[C@@]1(C)CO1)CC2=CC=CC=C2)=O)NC([C@H](CC=3C=4C(NC3)=CC=CC4)NC(CCCCC)=O)=O)C=5C=6C(NC5)=CC=CC6
Molecular Formula
C40H45N5O5
Molecular Weight
675.82
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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