Theophylline-platinum (IV) prodrug-1

Stem Cells, DNA Damage/DNA Repair, Chromatin/Epigenetic, NF-κB, Immunology/Inflammation, MAPK, JAK/STAT signaling, Apoptosis, Angiogenesis, Tyrosine Kinase/Adaptors, Cytoskeletal Signaling

Theophylline-platinum (IV) prodrug-1 is a PARP-1 inhibitor. It enhances DNA damage, ROS generation, mitochondrial dysfunction, apoptosis, and S-phase arrest in SKOV3-BRCA1-KD cells while reducing invasion and metastasis. Additionally, it exhibits strong antitumor activity in SKOV3-BRCA1-KD xenograft tumor models. This compound is used for ovarian cancer research.