JAK2-IN-13
Product Specifications
Target
STAT, JAK
Related Pathways
Stem Cells, Tyrosine Kinase/Adaptors, Chromatin/Epigenetic, JAK/STAT signaling, Angiogenesis
Bioactivity
JAK2-IN-13 is a potent and orally active JAK2 inhibitor with an IC50 of 54.7 nM. It downregulates the expression of p-STAT3 and p-STAT5 and exhibits good bioavailability. JAK2-IN-13 effectively suppresses recombinant human erythropoietin-induced extramedullary erythropoiesis as well as polycythemia vera. It is used in the study of myeloproliferative neoplasms.
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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