Nrf2-IN-4
Product Specifications
CAS Number
2417486-06-5
Target
Nrf2, ROS, Ferroptosis, ATG
Related Pathways
Immunology/Inflammation, Apoptosis, Autophagy
Bioactivity
Nrf2-IN-4 is an Nrf2 inhibitor that induces ferroptosis by disrupting cellular iron homeostasis, promoting ferritin degradation, and ultimately triggering ferroptosis. It activates lysosomes through iron-dependent reactive oxygen species (ROS) production and lysosomal acidification. Nrf2-IN-4 demonstrates significant antitumor effects and is applicable in breast cancer research.
Smiles
ClC=1C=CC(=CC1Cl)C=2N=C(SC2)NN=C(C3=NC=CC=C3)C4=NC=CC=C4
Molecular Formula
C20H13Cl2N5S
Molecular Weight
426.32
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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