PROTAC IRAK4 degrader-13
Product Specifications
CAS Number
2432992-21-5
Target
PROTACs, IRAK, TLR, Interleukin
Related Pathways
Immunology/Inflammation, PROTAC, NF-κB
Bioactivity
PROTACIRAK4 degrader-13 (Degrader 1) is a selective IRAK4 PROTAC degrader, demonstrating DC50 values of 0.86 nM and 1.1 nM in monocytes and lymphocytes within PBMCs, respectively. It significantly induces TIR signaling activation and inhibits the expression of circulating pro-inflammatory cytokines in a psoriasis mouse model induced by Imiquimod. PROTACIRAK4 degrader-13 is applicable in the study of neutrophilic inflammatory diseases driven by TLR and IL-1R, such as hidradenitis suppurativa (HS) and atopic dermatitis (AD) .
Smiles
C(C1=C2C(N(C(=O)N2C)C3C(=O)NC(=O)CC3)=CC=C1)N4CCC(N(C[C@@H]5CC[C@H](CC5)N6C=C7C(=N6)C=C(C(C)(C)O)C(NC(=O)C=8N=C(C(F)(F)F)C=CC8)=C7)C)CC4
Molecular Formula
C44H52F3N9O5
Molecular Weight
843.94
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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