VS1150
Product Specifications
CAS Number
2855238-97-8
Target
Caspase, PARP, Apoptosis, STAT, ERK, Bcr-Abl
Related Pathways
Cytoskeletal Signaling, Chromatin/Epigenetic, Tyrosine Kinase/Adaptors, Proteases/Proteasome, Apoptosis, MAPK, Stem Cells, JAK/STAT signaling, DNA Damage/DNA Repair, Angiogenesis
Bioactivity
VS1150 (Compound 11) is a phosphorylation-inducing chimeric small molecule (PHICS) designed to target BCR-ABL. It effectively hinders oncogenic kinase BCR-ABL signaling through inhibitory phosphorylation at the Y253 site (EC50: 69 nM), leading to apoptosis. Additionally, VS1150 can inhibit other oncogenic ABL fusion proteins and resistant mutants, such as T315I. This compound is applicable in research on chronic myeloid leukemia (CML) and other cancers driven by ABL fusion proteins.
Smiles
O=C(NC1=NN(C2=CC=C(Cl)C(Cl)=C2)CC1)C3=CN=C(N=C3C)NCCOCCOCCNC4=NC=C(C(=O)NC5=NN(C6=CC=C(Cl)C(Cl)=C6)CC5)C(=N4)C
Molecular Formula
C36H38Cl4N12O4
Molecular Weight
844.58
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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