What is the catalog number for VS1150?

The catalog number for VS1150 is T211881.

What sizes are available for VS1150?

VS1150 is available in the following size(s): 10 mg, 50 mg.

How many pack sizes does VS1150 come in?

VS1150 is available in 2 different pack sizes.

VS1150 is currently made to order / not held in immediate stock. Contact us for lead time.

Who manufactures VS1150?

VS1150 is manufactured by Molfinity.

What is the estimated delivery time for VS1150?

Estimated delivery time for VS1150 is approximately 10 business day(s), depending on your location.

VS1150

Product Specifications

CAS Number

2855238-97-8

Target

Caspase, PARP, Apoptosis, STAT, ERK, Bcr-Abl

Related Pathways

Cytoskeletal Signaling, Chromatin/Epigenetic, Tyrosine Kinase/Adaptors, Proteases/Proteasome, Apoptosis, MAPK, Stem Cells, JAK/STAT signaling, DNA Damage/DNA Repair, Angiogenesis

Bioactivity

VS1150 (Compound 11) is a phosphorylation-inducing chimeric small molecule (PHICS) designed to target BCR-ABL. It effectively hinders oncogenic kinase BCR-ABL signaling through inhibitory phosphorylation at the Y253 site (EC50: 69 nM), leading to apoptosis. Additionally, VS1150 can inhibit other oncogenic ABL fusion proteins and resistant mutants, such as T315I. This compound is applicable in research on chronic myeloid leukemia (CML) and other cancers driven by ABL fusion proteins.