AZ'320

AZ'320 is an ATP-competitive necroptosis inhibitor with an EC50 value of 4.9 μM and a RIPK1 inhibitor with a pKD value of 5.45. It functions by inhibiting RIPK1 phosphorylation, thereby suppressing necroptosis. In systemic inflammatory response syndrome (SIRS) model mice, AZ'320 reduces mortality and restores temperature and weight. This compound can be utilized in cancer and inflammation research.