MAPK-IN-5
Product Specifications
CAS Number
2579683-39-7
Target
ROS|||p38 MAPK|||Caspase|||PARP|||Bcl-2 Family|||Apoptosis
Related Pathways
DNA Damage/DNA Repair|||Proteases/Proteasome|||Apoptosis|||Immunology/Inflammation|||Chromatin/Epigenetic|||MAPK
Bioactivity
MAPK-IN-5 is a potent inhibitor of MAPK, with an IC50 value of 1.35 ?M in HeLa cells. It induces ROS-mediated DNA damage and mitochondrial apoptosis (apoptosis) via the MAPK pathway. MAPK-IN-5 significantly inhibits colony formation in HeLa cells, reduces viable cell numbers, suppresses cell migration, and arrests the cell cycle at the G2/M phase. It is applicable in cervical cancer research.
Smiles
FC(F)(F)C1=CC=C(C=C1)CN2N=NC(=C2)C=3C=CC=C(C3)NC=4N=CN=C5C=C(OCCOC)C(OCCOC)=CC54
Molecular Formula
C30H29F3N6O4
Molecular Weight
594.58
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
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