JAK3-IN-18
Product Specifications
CAS Number
2914873-59-7
Target
JAK, Tyrosinase
Related Pathways
Stem Cells, Angiogenesis, JAK/STAT signaling, Proteases/Proteasome, Tyrosine Kinase/Adaptors, Chromatin/Epigenetic
Bioactivity
JAK3-IN-18 is a selective and orally active dual inhibitor targeting JAK3 and TEC, with IC50 values of 0.5391 nM and 12.40 nM, respectively. It demonstrates remarkable selectivity for AK1, AK2, and TYK2, with selectivity ratios exceeding 10,000-fold. JAK3-IN-18 exhibits exceptional therapeutic efficacy in a mouse model of experimental autoimmune encephalomyelitis and is applicable for multiple sclerosis research.
Smiles
N([C@@H]1C=2C(CN(C(C=C)=O)C1)=CC(F)=CC2)C3=C4C(NC=C4)=NC=N3
Molecular Formula
C18H16FN5O
Molecular Weight
337.35
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
Frequently Asked Questions
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