FHND5032
Product Specifications
CAS Number
3076057-63-8
Target
Interleukin, PI3K, Akt, Antibacterial
Related Pathways
Cytoskeletal Signaling, PI3K/Akt/mTOR signaling, Immunology/Inflammation, Microbiology/Virology
Bioactivity
FHND5032 is an orally active miR-124 inducer that significantly enhances miR-124 expression in macrophages. It inhibits the PIK3R2/PI3K/Akt axis to block inflammatory signaling, facilitates macrophage reprogramming, and restores epithelial barrier function. FHND5032 alleviates colitis and reduces inflammatory burden in ulcerative colitis mouse models, making it useful for ulcerative colitis research.
Smiles
FC(F)(F)OC1=CC=C(C=C1)NC=2N=CC3=CC=C(Cl)C=C3N2
Molecular Formula
C15H9ClF3N3O
Molecular Weight
339.7
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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