TNI-97
Product Specifications
CAS Number
2790425-52-2
Target
Apoptosis, Necroptosis, Pyroptosis, HDAC
Related Pathways
Immunology/Inflammation, Apoptosis, Chromatin/Epigenetic, DNA Damage/DNA Repair
Bioactivity
TNI-97 is a selective, orally active HDAC6 inhibitor with an IC50 value of 0.2 nM. It significantly suppresses the growth and colony-forming abilities of the triple-negative breast cancer (TNBC) cell line MDA-MB-453. In these cells, TNI-97 induces widespread cell death, including apoptosis, necroptosis, and pyroptosis. Additionally, TNI-97 demonstrates antitumor activity in mouse models bearing MDA-MB-453 xenograft tumors or syngeneic mouse-derived TNBC cell allograft tumors. TNI-97 is useful for researching triple-negative breast cancer.
Smiles
O=C(NO)C1=CC=C(C=C1)CN2N=C(C=C2C(F)(F)F)C3=CC=C4C(N=NN4C)=C3
Molecular Formula
C19H15F3N6O2
Molecular Weight
416.36
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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