HW201877
Product Specifications
CAS Number
2927452-83-1
Target
Dehydrogenase
Related Pathways
Metabolism
Bioactivity
HW201877 is a potent, orally active inhibitor of 15-prostaglandin dehydrogenase (15-PGDH), with an IC50 value of 3.6 nM. It significantly increases PEG2 levels in A549 cells and demonstrates notable efficacy in animal models of tissue injury and fibrosis. HW201877 is utilized in research for inflammatory bowel disease (IBD), idiopathic pulmonary fibrosis (IPF), and Crohn's disease (CD) .
Smiles
C(=O)(C=1C=C2[C@]3([C@](C3)(CN(C2=NC1)C4=CC=5N(C=C4)C(=O)N(C)N5)[H])[H])N6CCC(F)(F)CC6
Molecular Formula
C22H22F2N6O2
Molecular Weight
440.45
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
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