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HW201877

Product Specifications

CAS Number

2927452-83-1

Target

Dehydrogenase

Related Pathways

Metabolism

Bioactivity

HW201877 is a potent, orally active inhibitor of 15-prostaglandin dehydrogenase (15-PGDH), with an IC50 value of 3.6 nM. It significantly increases PEG2 levels in A549 cells and demonstrates notable efficacy in animal models of tissue injury and fibrosis. HW201877 is utilized in research for inflammatory bowel disease (IBD), idiopathic pulmonary fibrosis (IPF), and Crohn's disease (CD) .

Smiles

C(=O)(C=1C=C2[C@]3([C@](C3)(CN(C2=NC1)C4=CC=5N(C=C4)C(=O)N(C)N5)[H])[H])N6CCC(F)(F)CC6

Molecular Formula

C22H22F2N6O2

Molecular Weight

440.45

Shipping Conditions

Cool pack

Storage Temperature

-20°C

Available Sizes

Curated Selection

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