What is the catalog number for ARN25657?

The catalog number for ARN25657 is T211728.

What sizes are available for ARN25657?

ARN25657 is available in the following size(s): 10 mg, 50 mg.

How many pack sizes does ARN25657 come in?

ARN25657 is available in 2 different pack sizes.

Is ARN25657 in stock?

ARN25657 is currently made to order / not held in immediate stock. Contact us for lead time.

Who manufactures ARN25657?

ARN25657 is manufactured by Molfinity.

What is the estimated delivery time for ARN25657?

Estimated delivery time for ARN25657 is approximately 10 business day(s), depending on your location.

ARN25657

Product Specifications

Target

P-gp, PKA, Dopamine Receptor, GSK-3

Related Pathways

PI3K/Akt/mTOR signaling, Neuroscience, Tyrosine Kinase/Adaptors, Stem Cells, GPCR/G Protein, Membrane transporter/Ion channel

Bioactivity

ARN25657 is a dual regulator of D3R/GSK-3β. It demonstrates partial agonist activity at the D3 receptor (EC50 = 15.2 nM, Ki = 1.5 nM) alongside potent inhibitor activity against GSK-3β (IC50 = 19.3 nM) . ARN25657 shows excellent GSK-3β selectivity over FYN, PKA, and CDK5/p35. It inhibits P-gp-mediated efflux of acetoxymethyl calcein, enhancing in vitro ADME properties while maintaining balanced dual-target distribution. ARN25657 is applicable in the study of bipolar disorder and related neuropsychiatric conditions.