ARN25657
Product Specifications
Target
P-gp|||PKA|||Dopamine Receptor|||GSK-3
Related Pathways
PI3K/Akt/mTOR signaling|||Neuroscience|||Tyrosine Kinase/Adaptors|||Stem Cells|||GPCR/G Protein|||Membrane transporter/Ion channel
Bioactivity
ARN25657 is a dual regulator of D3R/GSK-3?. It demonstrates partial agonist activity at the D3 receptor (EC50 = 15.2 nM, Ki = 1.5 nM) alongside potent inhibitor activity against GSK-3? (IC50 = 19.3 nM) . ARN25657 shows excellent GSK-3? selectivity over FYN, PKA, and CDK5/p35. It inhibits P-gp-mediated efflux of acetoxymethyl calcein, enhancing in vitro ADME properties while maintaining balanced dual-target distribution. ARN25657 is applicable in the study of bipolar disorder and related neuropsychiatric conditions.
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
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