Yoda2
Product Specifications
CAS Number
3081450-95-2
Target
Piezo Channel, NO Synthase
Related Pathways
Membrane transporter/Ion channel, Immunology/Inflammation
Bioactivity
Yoda2 (KC289), the potassium salt of Yoda1, is an agonist of PIEZO1 with an EC50 of 150 nM. It induces Ca2+ elevation in HeLa cells and can cause concentration-dependent and NO-dependent relaxation in mouse portal vein (EC50= 1.2 μM) . Additionally, Yoda2 is capable of stimulating NOS3 and promoting NO production.
Smiles
O=C(C1=CC=C(C2=NN=C(SCC3=C(Cl)C=CC=C3Cl)S2)C=C1)[O-].[K+]
Molecular Formula
C16H9Cl2KN2O2S2
Molecular Weight
435.39
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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