ISM7594
Product Specifications
CAS Number
3025799-76-9
Target
FGFR
Related Pathways
Tyrosine Kinase/Adaptors, Angiogenesis
Bioactivity
ISM7594 is an orally active FGFR2/3 inhibitor demonstrating broad-spectrum antiproliferative capabilities in cancer cell lines with FGFR2 or FGFR3 alterations, such as amplification, fusion, and mutation (e.g., BaF3-TEL-FGFR2-V564F with an IC50 of 0.067 nM, BaF3-TEL-FGFR2-V564I with an IC50 of 2 nM) . It inhibits tumor growth in a dose-dependent manner and is suitable for research on advanced solid tumors with FGFR2/3 abnormalities.
Smiles
O=C(N)C1=C2C=C(C=NN2C(C=3C=CC(=CC3)NC(=O)C(F)=C)=C1C4=CC=C(OC5=NC=CC(=N5)C)C(F)=C4)C
Molecular Formula
C29H22F2N6O3
Molecular Weight
540.52
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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