PIM1-IN-8
Product Specifications
Target
Interleukin|||NF-?B|||Pim
Related Pathways
NF-?B|||JAK/STAT signaling|||Immunology/Inflammation|||Chromatin/Epigenetic
Bioactivity
PIM1-IN-8 is an inhibitor targeting the PIM1/p65 signaling pathway. It suppresses the expression of ?-SMA and type I collagen in activated fibroblasts and inhibits TGF-?-induced migration. In a Bleomycin (BLM) -induced pulmonary fibrosis mouse model, PIM1-IN-8 alleviates lung fibrosis. This compound can be utilized in research on idiopathic pulmonary fibrosis (IPF) .
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
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