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PfPK6-IN-1

Product Specifications

CAS Number

2417648-94-1

Target

Parasite

Related Pathways

Microbiology/Virology

Bioactivity

PfPK6-IN-1 is a potent and selective inhibitor of PfPK6 with an IC50 value of 0.3 μM. It inhibits the formation of malarial pigment, affecting the unique heme detoxification pathway specific to the parasite, with an IC50 of 13 μM for β-hematin (βH) . PfPK6-IN-1 demonstrates rapid and broad-spectrum antimalarial properties, effective against both sensitive and drug-resistant strains of the parasite. This compound can be utilized in research on antimalarial agents.

Smiles

O=C(NC1=NC=CC(OC=2C=CC=3N=C(NC4=CC=C(C(=C4)C(F)(F)F)CN5CCN(CC)CC5)N(C3C2)C)=C1)C6CCN(C)CC6

Molecular Formula

C34H41F3N8O2

Molecular Weight

650.74

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

Available Sizes

Frequently Asked Questions

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