PfPK6-IN-1
Product Specifications
CAS Number
2417648-94-1
Target
Parasite
Related Pathways
Microbiology/Virology
Bioactivity
PfPK6-IN-1 is a potent and selective inhibitor of PfPK6 with an IC50 value of 0.3 ?M. It inhibits the formation of malarial pigment, affecting the unique heme detoxification pathway specific to the parasite, with an IC50 of 13 ?M for ?-hematin (?H) . PfPK6-IN-1 demonstrates rapid and broad-spectrum antimalarial properties, effective against both sensitive and drug-resistant strains of the parasite. This compound can be utilized in research on antimalarial agents.
Smiles
O=C(NC1=NC=CC(OC=2C=CC=3N=C(NC4=CC=C(C(=C4)C(F)(F)F)CN5CCN(CC)CC5)N(C3C2)C)=C1)C6CCN(C)CC6
Molecular Formula
C34H41F3N8O2
Molecular Weight
650.74
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
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