NCI677397
Product Specifications
CAS Number
907547-06-2
Target
Glutathione Peroxidase, DUB, ROS, Ferroptosis, Autophagy
Related Pathways
DNA Damage/DNA Repair, Cell Cycle/Checkpoint, Ubiquitination, Autophagy, Immunology/Inflammation, Metabolism, Apoptosis
Bioactivity
NCI677397 is a USP24 inhibitor. It enhances lipid ROS, activates cholesterol and fatty acid biosynthesis, and degrades ABC transporters, GPX4, and DHFR through the autophagy pathway. This process reduces p-gp levels, ultimately leading to ferroptosis in drug-resistant cancer cells. NCI677397 is relevant for research in lung and brain cancers.
Smiles
O=C(C=1C=CC=CC1)C2=CC=C3SC=4C=CC=CC4N(C3=C2)CCCCN5CCN(C)CC5
Molecular Formula
C28H31N3OS
Molecular Weight
457.63
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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