XIAP-CASP7 PPI-IN-1
Product Specifications
Target
Apoptosis|||Caspase|||Wnt/beta-catenin
Related Pathways
Stem Cells|||Apoptosis|||Cytoskeletal Signaling|||Proteases/Proteasome
Bioactivity
XIAP-CASP7 PPI-IN-1 is a reversible inhibitor of the XIAP:CASP7 interaction, effectively disrupting the connection between XIAP and CASP7. It selectively induces apoptosis in MCF-7 and caspase-3 low-expression (CASP3/DR) triple-negative breast cancer cells. The compound overcomes chemoresistance by down-regulating ?-catenin and associated ABC transporters in paclitaxel-resistant MCF-7 cells. XIAP-CASP7 PPI-IN-1 is useful for breast cancer research.
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
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