Nsp12-IN-2
Product Specifications
CAS Number
667882-55-5
Target
SARS-CoV|||Drug Metabolite|||Virus Protease
Related Pathways
Microbiology/Virology|||Metabolism
Bioactivity
Nsp12-IN-2 (Compound 8), a triphosphate metabolite of 4'-thiouridine, functions as an inhibitor of SARS-CoV-2 Nsp12. It effectively suppresses the RNA-dependent RNA polymerase (RdRp) activity of the SARS-CoV-2 Nsp12-Nsp7-Nsp8 complex, halting RNA synthesis and blocking the RNA capping and NMP capping of Nsp9. Nsp12-IN-2 shows potential for research into infections caused by SARS-CoV-2, other coronaviruses, and additional RNA viruses.
Smiles
O[C@H]1[C@H](N2C(NC(C=C2)=O)=O)S[C@@H]([C@H]1O)COP(OP(OP([O-])(O)=O)([O-])=O)([O-])=O.[Na+].[Na+].[Na+]
Molecular Formula
C9H12N2Na3O14P3S
Molecular Weight
566.15
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
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