NEP162
Product Specifications
CAS Number
3031840-36-2
Target
Apoptosis|||PROTACs|||Epigenetic Reader Domain
Related Pathways
Chromatin/Epigenetic|||Apoptosis|||PROTAC
Bioactivity
NEP162 is a BRD4 PROTAC degrader with DC50 values of 1.2 ?M in SW480 cells and 1.6 ?M in U2OS cells. NEP162 exhibits antiproliferative activity, effectively inhibiting tumor growth and inducing apoptosis. It is applicable in research on cancers such as osteosarcoma, colorectal cancer, and non-small cell lung cancer.
Smiles
CC=1C2=C(N3C([C@H](CC(=O)N4CCN(CCCOC=5C=C6C(=CC5)N=C(N6)[C@@H]7CC[C@H](NC(CNCC8=CC=9C(N8)=CC=CC9)=O)CC7)CC4)N=C2C%10=CC=C(Cl)C=C%10)=NN=C3C)SC1C
Molecular Formula
C50H56ClN11O3S
Molecular Weight
926.57
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
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