What is the catalog number for TNKS-2-IN-3?

The catalog number for TNKS-2-IN-3 is T211575.

What sizes are available for TNKS-2-IN-3?

TNKS-2-IN-3 is available in the following size(s): 10 mg, 50 mg.

How many pack sizes does TNKS-2-IN-3 come in?

TNKS-2-IN-3 is available in 2 different pack sizes.

Is TNKS-2-IN-3 in stock?

TNKS-2-IN-3 is currently made to order / not held in immediate stock. Contact us for lead time.

Who manufactures TNKS-2-IN-3?

TNKS-2-IN-3 is manufactured by Molfinity.

What is the estimated delivery time for TNKS-2-IN-3?

Estimated delivery time for TNKS-2-IN-3 is approximately 10 business day(s), depending on your location.

TNKS-2-IN-3

Product Specifications

CAS Number

2580941-64-4

Target

PARP

Related Pathways

DNA Damage/DNA Repair, Chromatin/Epigenetic

Bioactivity

TNKS-2-IN-3 (Compound 5) is a selective and competitive inhibitor of Tankyrase 2 (TNKS2), with an IC50 value of 0.3 nM. It exhibits over 20-fold selectivity for TNKS2 compared to TNKS1 and more than 100-fold selectivity over PARP1/2. By inhibiting TNKS2-mediated ADP ribosylation, TNKS-2-IN-3 stabilizes axin and suppresses the Wnt/β-catenin pathway, demonstrating antiproliferative activity in colorectal cancer cells. TNKS-2-IN-3 holds potential for research in solid tumors with aberrant Wnt pathway activation, such as colorectal cancer.