TNKS-2-IN-3
Product Specifications
CAS Number
2580941-64-4
Target
PARP
Related Pathways
DNA Damage/DNA Repair|||Chromatin/Epigenetic
Bioactivity
TNKS-2-IN-3 (Compound 5) is a selective and competitive inhibitor of Tankyrase 2 (TNKS2), with an IC50 value of 0.3 nM. It exhibits over 20-fold selectivity for TNKS2 compared to TNKS1 and more than 100-fold selectivity over PARP1/2. By inhibiting TNKS2-mediated ADP ribosylation, TNKS-2-IN-3 stabilizes axin and suppresses the Wnt/?-catenin pathway, demonstrating antiproliferative activity in colorectal cancer cells. TNKS-2-IN-3 holds potential for research in solid tumors with aberrant Wnt pathway activation, such as colorectal cancer.
Smiles
O=C1N=C(SCCN2CCN(CCSC3=NC(=O)C=4C=CC=CC4N3)CC2)NC=5C=CC=CC15
Molecular Formula
C24H26N6O2S2
Molecular Weight
494.63
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
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