What is the catalog number for PI3Kδ/HDAC6-IN-1?

The catalog number for PI3Kδ/HDAC6-IN-1 is T211563.

What sizes are available for PI3Kδ/HDAC6-IN-1?

PI3Kδ/HDAC6-IN-1 is available in the following size(s): 10 mg, 50 mg.

How many pack sizes does PI3Kδ/HDAC6-IN-1 come in?

PI3Kδ/HDAC6-IN-1 is available in 2 different pack sizes.

Is PI3Kδ/HDAC6-IN-1 in stock?

PI3Kδ/HDAC6-IN-1 is currently made to order / not held in immediate stock. Contact us for lead time.

Who manufactures PI3Kδ/HDAC6-IN-1?

PI3Kδ/HDAC6-IN-1 is manufactured by Molfinity.

What is the estimated delivery time for PI3Kδ/HDAC6-IN-1?

Estimated delivery time for PI3Kδ/HDAC6-IN-1 is approximately 10 business day(s), depending on your location.

PI3Kδ/HDAC6-IN-1

Product Specifications

CAS Number

3075011-99-0

Target

HDAC, ROS, PI3K, Microtubule Associated, Bcl-2 Family, Caspase, Histone Methyltransferase, Apoptosis

Related Pathways

Cytoskeletal Signaling, DNA Damage/DNA Repair, Proteases/Proteasome, Apoptosis, Immunology/Inflammation, PI3K/Akt/mTOR signaling, Chromatin/Epigenetic

Bioactivity

PI3Kδ/HDAC6-IN-1 (Compound 22E) is an orally active dual inhibitor of PI3Kδ and HDAC6, with IC50 values of 2.4 nM and 6.2 nM, respectively. It exhibits potent antiproliferative effects against non-Hodgkin's lymphoma (NHL) cells and demonstrates antitumor activity in vivo without significant toxicity. PI3Kδ/HDAC6-IN-1 induces cell cycle arrest at the G0/G1 phase and triggers apoptosis. Additionally, it inhibits the PI3K/AKT/mTOR signaling pathway and enhances the acetylation levels of α-tubulin and histone H3.